A method is for setting a contrast of a multi-energy CT image representation. In an embodiment of the method, a plurality of multispectral image datasets of an examination region of a patient are received. Furthermore, an automated identification of a structure to be examined is achieved based upon the multispectral image datasets and an automated combining of the differently weighted multispectral image datasets is accomplished such that the contrast between the structure to be examined and its environment is improved compared to a uniform weighting. Further, a multi-energy CT imaging method is described. An image setting device is also described. In addition, a computed tomography system is described.