An array substrate, a manufacturing method thereof and a display panel are provided. The array substrate includes a base substrate and a wiring layer. The base substrate includes a peripheral region, a bending region and a driving circuit region. The bending region is arranged between the driving circuit region and the peripheral region. A portion of the base substrate at the bending region is a stress buffer member arranged at an end of the bending region adjacent to the peripheral region, connected to a portion of the base substrate at the peripheral region, and spaced apart from a portion of the base substrate at the driving circuit region.