A fixing device for soft tissue includes: a driving device, screw tube and a drive rod. A catheter is connected with the screw tube by screw thread, and a plurality of absorbable screws or titanium screws are provided in the catheter. A screw thread structure is formed on a nailed beam of each of the absorbable screws, and a lead spring is provided on each of the absorbable screws. The plurality of absorbable screws or titanium screws are connected in series and provided in the catheter with a spiral groove in a head-to-nail sequence. When used, by pulling the trigger, the driving rod is rotated driven by the driving device, in such a manner that the absorbable screw or the titanium screw can be shot out of the catheter one by one. The fixing device of the present invention has characteristics of anti-adhesion, convenient and reliable operation.