A ligation clip applier is provided and includes a handle assembly supporting an advancing mechanism removably and slidably supported within a barrel housing of the handle assembly, and a clip module removably and selectively connected to the handle assembly. The clip module includes a housing defining a proximal end, a distal end and a lumen therethrough, the clip module housing including an annular flange extending radially into the lumen thereof; and a jaw blade slidably supported within the lumen of the clip module housing. The jaw blade includes a pair of jaws disposed within the distal end of the clip module housing, the pair of jaws being biased to an open condition, wherein each jaw includes a respective cam tooth projecting therefrom, wherein the cam teeth are in operative registration with, and proximal of, the annular flange of the clip module housing.