Invention Grant
- Patent Title: Norrin regulation of cellular production of junction proteins and use to treat retinal vasculature edema
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Application No.: US16182252Application Date: 2018-11-06
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Publication No.: US10703787B2Publication Date: 2020-07-07
- Inventor: Michael T. Trese , Antonio Capone , Kimberly Drenser
- Applicant: RETINAL SOLUTIONS LLC
- Applicant Address: US MI Ann Arbor
- Assignee: RETINAL SOLUTIONS LLC
- Current Assignee: RETINAL SOLUTIONS LLC
- Current Assignee Address: US MI Ann Arbor
- Agency: Blue Filament Law PLLC
- Main IPC: A61K38/18
- IPC: A61K38/18 ; A61P27/02 ; A61K39/395 ; C07K14/47 ; A61K38/17 ; C07K14/475 ; C07K14/515 ; C07K16/22 ; A61K38/00
Abstract:
A method of tightening inter-cellular junctions in retinal or choroidal vessel cells includes exposing the retinal or choroidal vessel cells to norrin and an anti-VEGF agent. Upon sufficient contact time, for norrin to selectively up-regulate gene expression of VE-cadherin or claudin-5 in the retinal or choroidal vessel cells, the inter-cellular junctions are tightened. The method is also suitable for treating retinal pigment epithelial cells in wet macular degeneration.
Public/Granted literature
- US20190218263A1 NORRIN REGULATION OF CELLULAR PRODUCTION OF JUNCTION PROTEINS AND USE TO TREAT RETINAL VASCULATURE EDEMA Public/Granted day:2019-07-18
Information query
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