Invention Grant
- Patent Title: Use of noggin, an ALK5 inhibitor and a protein kinase c activator to produce endocrine cells
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Application No.: US15457956Application Date: 2017-03-13
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Publication No.: US10704025B2Publication Date: 2020-07-07
- Inventor: Jean Xu
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agency: Klarquist Sparkman, LLP
- Main IPC: C12N5/071
- IPC: C12N5/071
Abstract:
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.
Public/Granted literature
- US20170183630A1 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS Public/Granted day:2017-06-29
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