A quick disconnect coupling for connecting a tube to another structure, such as a structure defining a port. The quick disconnect coupling may include a tube including a retention shoulder, a swivel rotatably disposed on the tube, and an adapter defining a bore for receiving a portion of the tube. The swivel may be engageable with the adapter to trap the retention shoulder between the swivel and the adapter. The adapter may be engageable with a receiving structure defining a port and the port may be in fluid communication with a lumen of the tube when the swivel is engaged with the adapter.