Invention Grant
- Patent Title: Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential
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Application No.: US15882259Application Date: 2018-01-29
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Publication No.: US10705092B2Publication Date: 2020-07-07
- Inventor: James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson
- Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
- Applicant Address: US DC Washington
- Assignee: The Government of the United States of Americam as Represented by the Secretary of the Navy
- Current Assignee: The Government of the United States of Americam as Represented by the Secretary of the Navy
- Current Assignee Address: US DC Washington
- Agency: US Naval Research Laboratory
- Agent Roy Roberts
- Main IPC: G01N33/58
- IPC: G01N33/58
Abstract:
A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
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