Technologies for dynamically protecting memory of the mobile compute device include a main memory, a location sensor that produces sensor data indicative of a present location of the mobile compute device, a sensor hub communicatively coupled to the location sensor, and a security engine communicatively coupled to the sensor hub. The sensor hub determines a present location security zone of the mobile compute device based on the present location of the mobile compute device and a geofence policy, which maps locations to location security zones. The security engine encrypts the main memory of the mobile compute device and determines whether the present location security zone has changed relative to a most-previous location security zone of the mobile compute device. If the present location security zone has changed to a safe zone, the security engine decrypts the main memory.