A photonic structural and chemometric pathology system for cancer and precancerous or general detection, diagnosis, monitoring and prognosis utilizes fresh or frozen tissue standard pathology sections without prior as staining or other labeling techniques. The unlabeled tissue section may be imaged, with a phase and fluorescence imaging microscope, to obtain phase differential contrast (Q-DIC) images and fluorescence images. The Q-DIC images are analyzed to generate two dimensional Q-DIC data maps, such as morphology, cell mass, and scattering characteristic digital image maps. The fluorescence images are analyzed to generate fluorescence intensity and tissue native fluorescent component absolute concentration maps. The combination of Q-DIC data maps and fluorescent component content maps is comparatively analyzed to perform cancer and pre-cancerous or general diagnosis and prognosis. The system can be applied to a wide range of cancers and tissues for noninvasive and unlabeled cancer and pre-cancerous or general detection, diagnosis, monitoring and prognosis.