An energy acquisition and power supply system is provided. The power supply system includes a plurality of power elements, each of the power elements including a transistor capable of conduction path switching, a current regulator having a dynamic substrate selection circuit and a reverse leakage current suppression circuit as well as a voltage regulator, wherein the dynamic substrate selection circuit selects a substrate potential of the transistor capable of conduction path switching dynamically to reduce a substrate leakage current of the transistor capable of conduction path switching, and the reverse leakage current suppression circuit is utilized for switching the power element at a local end to reduce transient reverse leakage current and current consumption of the power element at the local end for an input voltage, such that an output current for the power element at the local end is maximized.