A radio frequency front-end (RFFE) bus hub circuit and related apparatus are provided. In examples discussed herein, the RFFE bus hub circuit can be configured to bridge an RFFE bus with a number of auxiliary RFFE buses. In a non-limiting example, each of the auxiliary RFFE buses can be configured to support up to fourteen RFFE slaves. Thus, by bridging the RFFE bus with multiple auxiliary RFFE buses using the RFFE bus hub circuit, it may be possible to support more than fifteen RFFE slaves without adding an additional RFFE bus. As a result, it may be possible to reduce pin count requirement for an RFFE master and/or enable flexible RFFE bus deployment in an RFFE apparatus.