The present disclosure discloses a method and device in user equipment and a base station for wireless communication. The base station equipment sequentially generates a first information block, performs first channel coding and transmits a first radio signal, wherein the first information block includes bits in a first sub-information block and padding bits, the first information block is used to generate a first check bit block, the first information block and the first check bit block are interleaved to generate the first bit block, and the first bit block is used as the input of the first channel coding; the bits in the first sub-information block are discontinuous in the first information block, or the padding bits are discontinuous in the first information block.