The present disclosure relates generally to firewall configuration management, and, more specifically, to managing firewall configurations using dynamically generated block lists. A computer-implemented method includes adding an entry as a record in a block list entries table and associating the entry with a block list in a block list table and with an observable in an observables table. The method also includes activating the entry in the block list entries table to allow or block subsequent occurrences of the observable on a client network. The method further includes receiving a request for the block list from a firewall disposed on the client network and, in response, generating the block list from activated entries in the block list table and block list entries table and sending the block list to the firewall, wherein the firewall is configured to allow or block network traffic associated with the observable on the client network in accordance with the block list.