Embodiments of the present invention relate to, in general, detecting and mitigating malicious communications. Typically, a system of the present invention is configured to deliver indicators of compromise in response to identifying and isolating malicious communication. Moreover, the system is configured to analyze an electronic communication to determine if it is malicious or if it has a malicious payload. In some embodiments, the system is configured to determine an indicator of compromise for the electronic communication determined to be malicious, and transmit this indicator of compromise to the first networked device. In some embodiments, the system transmits a threat trigger signal to a third party provider. The threat trigger signal is configured to allow an application or system provided by the third party provider to block a threat caused by the electronic communication. In some embodiments, the system provides training to help users better identify and report threats.