The disclosure concerns medical devices configured to utilize nitric oxide (NO) donor materials to release NO gas upon contact with moisture in order to mitigate bacterial proliferation, coagulation, or a combination thereof, at a site of a biosensor integrated within the medical device. A novel multi-lumen medical device is described, the device having a first lumen for containing the NO donor material and producing the NO gas, and having a second lumen for housing biosensor componentry. A channel between the first and second lumens serves to communicate NO gas from the first lumen to a sensor-volume of the biosensor.