An absorbent article with a fastening system with reduced waste and method of manufacturing such an absorbent article is disclosed. The method of manufacturing an absorbent article can include cutting a first web of ear tab material to provide a first ear tab that is registered and cutting a second web of ear tab material to provide a second ear tab that is registered. The method can also include providing a web of ear panel material, coupling the first and second ear tabs to the web of ear panel material, cutting the web of ear panel material to provide first and second ear panels to form first and second ears, and coupling the first and second ears to the absorbent assembly to form at least a portion of the fastening system for the absorbent article. The first and second ears can be configured to be different from one another.