Invention Grant
- Patent Title: FLT3 receptor inhibitor at low dosage for the treatment of neuropathic pain
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Application No.: US16307968Application Date: 2017-06-08
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Publication No.: US10709687B2Publication Date: 2020-07-14
- Inventor: Jean Valmier
- Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE DE MONTPELLIER , BIODOL THERAPEUTICS
- Applicant Address: FR Paris FR Montpellier FR Clapiers
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITE DE MONTPELLIER,BIODOL THERAPEUTICS
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITE DE MONTPELLIER,BIODOL THERAPEUTICS
- Current Assignee Address: FR Paris FR Montpellier FR Clapiers
- Agency: W&C IP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@365656d2
- International Application: PCT/EP2017/063935 WO 20170608
- International Announcement: WO2017/211937 WO 20171214
- Main IPC: A61K31/404
- IPC: A61K31/404 ; A61P25/02 ; A61P29/00 ; A61K9/00 ; A61K9/70 ; A61K31/497 ; A61K31/5377 ; A61K31/553 ; A61K31/44

Abstract:
The present invention relates to FLT3 receptor inhibitor for use in the treatment of neuropathic pain and chronic pain comprising a neuropathic component, wherein the daily dosage range per human adult per day of said FLT3 receptor inhibitor consists of a dosage range determined by a method comprising the steps of: (i) determining the minimal inhibiting dose of said FLT3 receptor inhibitor that induces the maximal inhibition of mechanical pain hypersensitivity, (ii) converting said dose to the Human Equivalent Dose (HED) by the allometric correction method, and (iii) establishing a daily dosage range per human adult per day wherein (iii-1) the lower limit of the said daily dosage range per human adult per day is the greater value between HED/20 determined via a rat model and 0.001 mg, and (iii-2) the upper limit of the said daily dosage range is the lower value between HED*20 determined via a rat model and 50 mg.
Public/Granted literature
- US20190298691A1 FLT3 RECEPTOR INHIBITOR AT LOW DOSAGE FOR THE TREATMENT OF NEUROPATHIC PAIN Public/Granted day:2019-10-03
Information query
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