Invention Grant
- Patent Title: Polymer composed of repeat units having a biologically active molecule attached thereto via a pH-sensitive bond
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Application No.: US15518737Application Date: 2015-10-13
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Publication No.: US10709717B2Publication Date: 2020-07-14
- Inventor: Myriam Marie Ouberai , Mark Welland
- Applicant: SPIREA LIMITED
- Applicant Address: GB Harrogate
- Assignee: SPIREA LIMITED
- Current Assignee: SPIREA LIMITED
- Current Assignee Address: GB Harrogate
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@39ac9628
- International Application: PCT/GB2015/053007 WO 20151013
- International Announcement: WO2016/059391 WO 20160421
- Main IPC: A61K31/13
- IPC: A61K31/13 ; A61K31/133 ; A61K31/138 ; A61K31/4409 ; A61K31/496 ; A61K31/573 ; A61K9/51 ; C08G63/672 ; A61K45/06 ; C08G63/685 ; C08G63/16 ; A61K47/59 ; C08G63/688 ; A61K9/50 ; C08G63/91 ; C12P7/62

Abstract:
There is provided a polymer comprising: (i) a repeat unit derived from a compound of formula (I) (Formula (I)) wherein, R1 and R2 are each independently selected from OH, OR′, SH, SR′, NH2, NHR′ and NR′2; R′ is C1-20 hydrocarbyl; each n is independently 0 or an integer between 1 and 6; each m is independently 0 or an integer between 1 and 4, and preferably at least one m is 1; and q is an integer between 1 and 8; and; (ii) a biologically active molecule, wherein said biologically active molecule is covalently bonded to said repeat unit; as well as methods for preparing such polymers, particles comprising said polymers and uses of said polymers and particles including use in the treatment of disease.
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