Invention Grant
- Patent Title: Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
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Application No.: US15875947Application Date: 2018-01-19
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Publication No.: US10709799B2Publication Date: 2020-07-14
- Inventor: Henry Bernard Lowman , Luc Roland Desnoyers , Shouchun Liu , James William West , Jason Gary Sagert , Olga Vasiljeva , Elizabeth-Edna Mary Menendez
- Applicant: CytomX Therapeutics, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: CytomX Therapeutics, Inc.
- Current Assignee: CytomX Therapeutics, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Cynthia A. Kozakiewicz
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/00 ; A61K49/00 ; G01N33/68 ; G01N33/58 ; G01N33/574 ; C07K16/28 ; A61K47/68 ; C07K16/30
Abstract:
The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these anti-EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
Public/Granted literature
- US20180333507A1 ACTIVATABLE ANTIBODIES THAT BIND EPIDERMAL GROWTH FACTOR RECEPTOR AND METHODS OF USE THEREOF Public/Granted day:2018-11-22
Information query
