Clog-resistant serpentine crossflow filters and blade loading structures for micro- and nano-fluidics are provided. In one aspect, a filter includes: a substrate; and at least one layer of pillars on the substrate, wherein the pillars are arranged adjacent to one another and groups of the pillars alternate between being perpendicular and parallel to a direction of fluid flow through the filter giving the filter a serpentine configuration having at least one downstream catch. A method of forming the filter as well as a system employing the filter in conjunction with a pillar sorting array and optionally a staged blade structure are also provided.