Invention Grant
![Processes for preparing (R)-1-(5-chloro-[1,1″-biphenyl] -2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1″-biphenyl]-2-yl)-2,2,2-trifluoroethanone](/docs/US/2020-07-14/US10710948B2/abs.jpg.600x600.jpg)
- Patent Title: Processes for preparing (R)-1-(5-chloro-[1,1″-biphenyl] -2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1″-biphenyl]-2-yl)-2,2,2-trifluoroethanone
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Application No.: US16546906Application Date: 2019-08-21
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Publication No.: US10710948B2Publication Date: 2020-07-14
- Inventor: Stéphane De Lombaert , Daniel R. Goldberg
- Applicant: Roivant Sciences GmbH
- Applicant Address: CH Basel
- Assignee: Roivant Sciences GmbH
- Current Assignee: Roivant Sciences GmbH
- Current Assignee Address: CH Basel
- Agency: Ohlandt, Greeley, Ruggiero & Perle L.L.P.
- Main IPC: C07C29/32
- IPC: C07C29/32 ; C07C29/143 ; C07C259/10 ; C07C45/45 ; C07C49/80
![Processes for preparing (R)-1-(5-chloro-[1,1″-biphenyl] -2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1″-biphenyl]-2-yl)-2,2,2-trifluoroethanone](/abs-image/US/2020/07/14/US10710948B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.
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