Invention Grant
- Patent Title: Method for reducing pluripotent stem cells, method for producing cell population having reduced pluripotent stem cells
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Application No.: US15755293Application Date: 2016-08-23
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Publication No.: US10711247B2Publication Date: 2020-07-14
- Inventor: Katsuhisa Matsuura , Tatsuya Shimizu , Hiroyoshi Seta
- Applicant: TOKYO WOMEN'S MEDICAL UNIVERSITY
- Applicant Address: JP Tokyo
- Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
- Current Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
- Current Assignee Address: JP Tokyo
- Agency: Kilpatrick Townsend & Stockton LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5197bbc
- International Application: PCT/JP2016/074545 WO 20160823
- International Announcement: WO2017/038562 WO 20170309
- Main IPC: C12N5/077
- IPC: C12N5/077 ; C12N5/074 ; C12N15/09 ; C12N5/10
Abstract:
The present invention pertains to a method for culturing a cell population including pluripotent stem cells and differentiated cells derived from pluripotent stem cells at a temperature of 40.5° C. or higher and reducing the pluripotent stem cells included in the cell population. The present invention also pertains to a method for reducing pluripotent stem cells from a cell population including pluripotent stem cells and differentiated cells derived from pluripotent stem cells, wherein the method includes a step for activating the TRPV-1 expressed in the pluripotent stem cells included in the cell population. The present invention makes it possible to reduce the pluripotent stem cells remaining in an undifferentiated state when inducing the differentiation of a pluripotent stem cell population.
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