Invention Grant
- Patent Title: Amino acid-modified nucleic acid and utilization thereof
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Application No.: US15579841Application Date: 2016-06-08
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Publication No.: US10711273B2Publication Date: 2020-07-14
- Inventor: Yoshio Kato , Naoshi Kojima
- Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
- Applicant Address: JP Tokyo
- Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
- Current Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
- Current Assignee Address: JP Tokyo
- Agency: Myers Bigel, P.A.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@16153d18
- International Application: PCT/JP2016/067025 WO 20160608
- International Announcement: WO2016/199801 WO 20161215
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/09 ; C12N15/67 ; C12N9/00
Abstract:
Provided is a method for synthesizing a protein, into which a nucleobase amino acid (NBA) is introduced at a desired position, that comprises: a step for preparing mRNA into which a modified codon is inserted at a desired position downstream of an initiation codon; and a step for translating the aforesaid mRNA into a protein in the presence of tRNA, said tRNA recognizing the modified codon and being acylated with the NBA. Also provided is a ribozyme that catalyzes the aminoacylation of tRNA and comprises two RNA molecules.
Public/Granted literature
- US20180251759A1 AMINO ACID-MODIFIED NUCLEIC ACID AND UTILIZATION THEREOF Public/Granted day:2018-09-06
Information query
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