A system of isolation management comprises a computer for generating an isolation plan; a lockbox configured to receive the isolation plan from the computer; a mobile device associated with an individual, and one or more locks for isolation locking of an asset by each individual according to the isolation plan. The mobile device is allocated to the lockbox according to the isolation plan. The lockbox is configured to recognise the mobile device when proximal to the lockbox. The one or more isolation locks are removably housed in the lockbox. The one or more isolation locks are each able to be recognised by the mobile device and the mobile device is configured to record an association of one or more of the isolation locks to the mobile device according to the isolation plan. There is also an isolation point for isolating the asset with the one or more isolation locks according to the isolation plan. The isolation point is able to be recognised by the mobile device.