A therapeutic pillow sham that allows a user to cover any body part such as, but not limited to, the eyes, neck, chest or back of the user. The therapeutic pillow sham includes a pillowcase, a first sash, and a second sash. The pillowcase is a pillow enclosure that is able to receive a pillow. The first sash and the second sash allow the user to cover any body part. In more detail, the first sash and the second sash can be used to cover the eyes of the user in order to block out light while the user is asleep and laying on the therapeutic pillow sham. Additionally, the first sash and the second sash can receive a therapeutic insert to provide therapeutic support to any body part.