A walking assistance device includes: a base frame; two front wheels, the two front wheels on a traveling side of the base frame; and one rear wheel. An operation frame including a holding grip for an operator is height-adjustably attached to the base frame. A first axle support with the axle of the front wheels fixed is attached to the base frame, whereby the front wheels retain in contact with the ground even when the operation frame tilts. The axle of the front wheels is positioned on the traveling direction side with respect to the leading end in the traveling direction of the base frame. Providing a gap and a stopper above the rear wheel and downward pressing against the holding grip allows the stopper to come into contact with the rear wheel.