A paper pickup mechanism includes a mechanical frame, a pickup roller module, a feeding roller module, a driving device, a separation roller module and an energy storage element. The mechanical frame has a platform. The pickup roller module is pivoted to and connected to the mechanical frame. The feeding roller module is pivoted to and connected to the mechanical frame. The driving device is mounted to the mechanical frame. The separation roller module is pivoted to and connected to the mechanical frame. The energy storage element is mounted between the mechanical frame and the separation roller module. When the separation roller module rotates together with the feeding roller module in a forward direction, the energy storage element accumulates energies. When more than one piece of paper is fed into the paper pickup mechanism, the energy storage element releases the energies.