Invention Grant
- Patent Title: Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
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Application No.: US16446360Application Date: 2019-06-19
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Publication No.: US10717722B2Publication Date: 2020-07-21
- Inventor: Anne-Marie Beausoleil , Ryan Hudson
- Applicant: Unity Biotechnology, Inc.
- Applicant Address: US CA Brisbane
- Assignee: Unity Biotechnology, Inc.
- Current Assignee: Unity Biotechnology, Inc.
- Current Assignee Address: US CA Brisbane
- Agency: Bozicevic, Field & Francis LLP
- Agent Rudy J. Ng
- Main IPC: C07D207/337
- IPC: C07D207/337 ; C07D401/12 ; C07D401/10 ; C07D403/10 ; A61P9/10 ; A61P35/00 ; A61P27/00 ; C07D401/14
Abstract:
The aryl sulfonamide compounds of this invention have powerful and cell-type specific Bcl inhibitory activity. Compounds of this invention include compounds according to formula (I): Selected compounds in this class promote apoptosis in senescent cells, and are being developed for treating senescent-related conditions. Selected compounds in this class promote apoptosis in cancer cells, and can be developed as chemotherapeutic agents.
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