- Patent Title: Solid forms of acalabrutinib and process for preparation thereof
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Application No.: US16620039Application Date: 2018-06-08
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Publication No.: US10717740B2Publication Date: 2020-07-21
- Inventor: Raja Sekhar Voguri , Vishweshwar Peddy
- Applicant: DR. REDDY'S LABORATORIES LIMITED
- Applicant Address: IN Hyderabad
- Assignee: DR. REDDY'S LABORATORIES LIMITED.
- Current Assignee: DR. REDDY'S LABORATORIES LIMITED.
- Current Assignee Address: IN Hyderabad
- Agency: Pergament & Cepeda LLP
- Agent Milagros A. Cepeda; Edward D. Pergament
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4ed6b5f
- International Application: PCT/IB2018/054146 WO 20180608
- International Announcement: WO2018/229613 WO 20181220
- Main IPC: C07D487/04
- IPC: C07D487/04
Abstract:
The present application relates to crystalline propylene glycol solvate of acalabrutinib and process for preparation thereof. The propylene glycol solvate of acalabrutinib may be selected from a group of racemic propylene glycol solvate, R-propylene glycol solvate and S-propylene glycol solvate of acalabrutinib. Specifically, the present application relates to crystalline forms RSV1, RSV2, RSV3 and RSV4 of acalabrutinib. Crystalline forms RSV2 and RSV3 are stable in all conditions and has excellent physico-chemical properties. The present application also relates to crystalline form RSVS of acalabrutinib.
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