Invention Grant
- Patent Title: Method for the manufacturing of 2-(3-(alkyl and alkenyl)morpholino)-ethan-1-ols
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Application No.: US16472399Application Date: 2017-12-20
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Publication No.: US10717747B2Publication Date: 2020-07-21
- Inventor: Carla De Faveri , Mariano Stivanello
- Applicant: Lundbeck Pharmaceuticals Italy S.p.A.
- Applicant Address: IT Padua
- Assignee: Lundbeck Pharmaceuticals Italy S.P.A.
- Current Assignee: Lundbeck Pharmaceuticals Italy S.P.A.
- Current Assignee Address: IT Padua
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@2e1b41f
- International Application: PCT/EP2017/083795 WO 20171220
- International Announcement: WO2018/115111 WO 20180628
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D295/023 ; C07D295/027

Abstract:
The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl and alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-5 propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.
Public/Granted literature
- US20190359632A1 METHOD FOR THE MANUFACTURING OF 2-(3-(ALKYL AND ALKENYL)MORPHOLINO)-ETHAN-1-OLS Public/Granted day:2019-11-28
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