Invention Grant
- Patent Title: Antibodies capable of specifically binding two epitopes on tissue factor pathway inhibitor
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Application No.: US15866007Application Date: 2018-01-09
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Publication No.: US10717784B2Publication Date: 2020-07-21
- Inventor: Berit O. Krogh , Mikael Kofod-Hansen , Ida Hilden , Helle H. Petersen , Lars C. Petersen , Jens Breinholt
- Applicant: Novo Nordisk A/S
- Applicant Address: DK Bagsvaerd
- Assignee: NOVO NORDISK A/S
- Current Assignee: NOVO NORDISK A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Rosemarie R. Wilk-Orescan
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@1c7bd15f
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C12P21/08 ; C07K16/00 ; C07K16/38 ; C07K16/46
Abstract:
The application discloses a combination of two monospecific TFPI antibodies, wherein one antibody is capable of specifically binding TFPI (1-181) and the other antibody is capable of specifically binding TFPI (182-276), as well as bispecific anti-TFPI antibodies derived from two such monospecific antibodies. Both the combination of the two monospecific antibodies and the bispecific antibody strongly enhance thrombin generation by neutralising full length TFPIα, even where the concentration of TFPI is abnormally elevated.
Public/Granted literature
- US20180208675A1 ANTIBODIES CAPABLE OF SPECIFICALLY BINDING TWO EPITOPES ON TISSUE FACTOR PATHWAY INHIBITOR Public/Granted day:2018-07-26
Information query
