Invention Grant
- Patent Title: Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free DNA
-
Application No.: US16146807Application Date: 2018-09-28
-
Publication No.: US10718010B2Publication Date: 2020-07-21
- Inventor: Chunxiao Song , Stephen R. Quake
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee Address: US CA Stanford
- Agency: Bozicevic, Field & Francis LLP
- Agent James S. Keddie
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/6855 ; C12Q1/6869 ; C12Q1/6806 ; C12Q1/6886 ; C40B40/08 ; C40B50/04 ; C40B70/00
Abstract:
Provided herein is a method of sequencing hydroxymethyated cell-free DNA. In some embodiments, the method comprises adding an affinity tag to only hydroxymethyated DNA molecules in a sample of cfDNA, enriching for the DNA molecules that are tagged with the affinity tag; and sequencing the enriched DNA molecules.
Public/Granted literature
- US20190017109A1 NONINVASIVE DIAGNOSTICS BY SEQUENCING 5-HYDROXYMETHYLATED CELL-FREE DNA Public/Granted day:2019-01-17
Information query
