Example apparatus, systems and methods for cloud-based simulation and control of building systems are disclosed and described herein. An example apparatus includes a control center including a processor configured to implement a modeler to generate a model of a target building infrastructure based on weather data, usage data, and building properties information. The example processor is configured to implement a building energy simulator to simulate energy usage for the target building using the model and scenario parameters. The example simulator is to simulate a plurality of scenarios with respect to the model to determine the configuration information for the one or more facility environmental controllers at the target building. The example simulator is to calculate a value associated with each simulated scenario and facilitate comparison of the values to generate the configuration information corresponding to a selected value to be selected from the values associated with the simulated scenarios.