An electronic device, method, and computer readable medium for multi-frame image processing using semantic saliency are provided. The electronic device includes a camera, a display, and a processor. The processor is coupled to the camera and the display. The processor receives a plurality of frames captured by the camera during a capture event; identifies a salient region in each of the plurality of frames; determines a reference frame from the plurality of frames based on the identified salient regions; fuses non-reference frames with the determined reference frame into a completed image output.