Methods, apparatus, systems and articles of manufacture to detect steganographically hidden content in a media file are disclosed. An example system includes a media classifier to determine type of a media file, and a detector to apply a detection technique to the media file. The detector selects the detection technique from a plurality of steganographically-based detection techniques based on the media file type. The system also includes a remediator to apply a remediation technique to the media file based on whether the detector detects steganographically hidden content in the media file.