A method, device, base station and UE for uplink transmission main carrier switch and control to enable the uplink transmission main carrier of the UE to switch among multiple different cells providing service for the UE, enhance the transmission flexibility of the uplink transmission main carrier of the UE, and at the same time take account of the transmission requirements of transmission power and UE services. The method for uplink transmission main carrier switch and control includes: determining the transmission resources of the cell set used for providing service for the UE, the transmission resources being configured for the user equipment (UE), wherein the transmission resources include the configured resources of uplink transmission carrier of multiple cells, the transmission resources being used for enabling the uplink transmission main carrier of UE to switch among the uplink transmission carriers corresponding to different cells; informing the UE of the transmission resource of the cell set.