A system includes an annular packer assembly configured to be positioned within an outer annular barrel. The annular packer assembly includes a packer having a radially-inner surface configured to contact an inner annular barrel and a radially-outer surface, and the packer extends axially from a first end to a second end. The annular packer assembly also includes a piston assembly configured to move axially relative to the outer annular barrel to deflect the second end of the packer radially-inwardly into an annular space between the inner annular barrel and the outer annular barrel to seal about the inner annular barrel.