Providing efficient multiplication of sparse matrices in matrix-processor-based devices is disclosed herein. In one aspect, a matrix processor of a matrix-processor-based device includes a plurality of sequencers coupled to a plurality of multiply/accumulate (MAC) units for performing multiplication and accumulation operations. Each sequencer determines whether a product of an element of a first input matrix to be multiplied with an element of a second input matrix has a value of zero (e.g., by determining whether the element of the first input matrix has a value of zero, or by determining whether either the element of the first input matrix or that of the second input matrix has a value of zero). If the product of the elements of the first input matrix and the second input matrix does not have a value of zero, the sequencer provides the elements to a MAC unit to perform a multiplication and accumulation operation.