A surgical clip includes a pair of opposed arms joined at one end by an integrally formed flexible hinge, which may contain multiple cut-out spaces or finger-like projections and may be severable. A male locking pin near the free end of one arm is configured to penetrate tissue when the male locking pin is urged towards a mating female aperture near the end of the opposite arm. The clamping side of an arm may include a protruding feature, such as a wedge shape elongated ridge, while the clamping side of the opposite arm includes a corresponding trough or aperture that receives the protruding feature. Clamping surfaces may include non-slip protrusions, such as ribs, ridges, cones or pins. Rectangular cross-section alignment guides are provided to maintain clip alignment in the applicator.