Invention Grant
- Patent Title: Method for cellular RNA expression
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Application No.: US16245353Application Date: 2019-01-11
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Publication No.: US10729784B2Publication Date: 2020-08-04
- Inventor: Ugur Sahin , Tim Beissert , Marco Poleganov , Stephanie Herz , Lars Koste
- Applicant: TRON TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ gGMBH , BIONTECH RNA PHARMACEUTICALS GMBH
- Applicant Address: DE Mainz DE Mainz
- Assignee: TRON TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSM,BIONTECH RNA PHARMACEUTICALS GMBH
- Current Assignee: TRON TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSM,BIONTECH RNA PHARMACEUTICALS GMBH
- Current Assignee Address: DE Mainz DE Mainz
- Agency: Elmore Patent Law Group, P.C.
- Agent Joseph C. Zucchero; Carolyn S. Elmore
- Main IPC: C12N15/00
- IPC: C12N15/00 ; A61K48/00 ; A61K31/52 ; A61K31/429 ; A61K38/16 ; C12N13/00 ; C12N5/074 ; C12P21/04
Abstract:
The present invention relates to expressing RNA in cells and, in particular, enhancing viability of cells in which RNA is to be expressed. Specifically, the present invention provides methods for expressing RNA in cells comprising the steps of preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells. Thus, preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells allows repetitive transfer of RNA into the cells.
Public/Granted literature
- US20190269793A1 METHOD FOR CELLULAR RNA EXPRESSION Public/Granted day:2019-09-05
Information query
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