Invention Grant
- Patent Title: Antigen-binding proteins targeting CD56 and uses thereof
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Application No.: US15884608Application Date: 2018-01-31
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Publication No.: US10730941B2Publication Date: 2020-08-04
- Inventor: Michel Sadelain , Reuben Benjamin , Dimiter S. Dimitrov , Yang Feng
- Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Applicant Address: US NY New York US MD Bethesda
- Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER,THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER,THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee Address: US NY New York US MD Bethesda
- Agency: Baker Botts L.L.P.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/705 ; C07K14/725 ; A61K35/17 ; A61P35/00 ; C07K16/30 ; A61K39/00
Abstract:
The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
Public/Granted literature
- US20180230214A1 ANTIGEN-BINDING PROTEINS TARGETING CD56 AND USES THEREOF Public/Granted day:2018-08-16
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