Invention Grant
- Patent Title: Antibodies reactive with B7-H3 and users thereof
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Application No.: US15861966Application Date: 2018-01-04
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Publication No.: US10730945B2Publication Date: 2020-08-04
- Inventor: Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
- Applicant: MacroGenics, Inc.
- Applicant Address: US MD Rockville
- Assignee: MacroGenics, Inc.
- Current Assignee: MacroGenics, Inc.
- Current Assignee Address: US MD Rockville
- Agency: AuerbachSchrot LLC
- Agent William C. Schrot; Jeffrey I. Auerbach
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/30 ; A61K39/395 ; A61K45/06 ; C07K16/28 ; G01N33/574 ; A61K47/68
Abstract:
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
Public/Granted literature
- US20180134790A1 Antibodies Reactive with B7-H3 and Uses Thereof Public/Granted day:2018-05-17
Information query
