Embodiments of the present disclosure relate to facilitating efficient access to electronic content via an intermediate caching layer between a client device and remote storage system. In particular, systems and methods disclosed herein generate and maintain a regional cache on a data center that includes a subset of digital content items from a collection of digital content items stored on the remote storage system. For example, in response to receiving a data request, the systems and methods disclosed herein determine whether a digital content item corresponding to the data request exists on an intermediate caching layer including both a local data center and one or more remote data centers. The systems and methods facilitate obtaining copies of requested digital content items from the regional caches when available, resulting in faster responses to data requests while decreasing a number of times a client directly accesses the remote storage system.