Systems, methods, and apparatus for communicating virtual GPIO information generated at multiple source devices and directed to multiple destination devices. A method performed at a device coupled to a serial bus includes generating first virtual GPIO state information representative of state of one or more physical GPIO output pins, asserting a request to transmit the first virtual GPIO state information by driving a data line of the serial bus from a first state to a second state after a start code has been transmitted on a serial bus and before a first clock pulse is transmitted on a clock line of the serial bus, transmitting the first virtual GPIO state information as a first set of bits in a data frame associated with the start code, and receiving second virtual GPIO state information in a second set of bits in the data frame.