Mechanisms for optimizing the determination of supplements for consumers are provided. A longevity inquiry is received from a remote device. A biological extraction is retrieved from a user database and is used with the longevity inquiry to identify a longevity element associated with a user. Further, an ADME model is selected that uses the biological extraction. A machine-learning algorithm is generated using the selected ADME model that uses the longevity element associated with the user as an input and outputs an ADME factor. A tolerant longevity element is identified utilizing the ADME factor.