Systems, methods and software are provided that include a cloud, internet, and/or browser, application, or server based medical image sharing method and system that shares at least one 2D image data file through an internet browser that can generate rotatable and manipulatable 3D and/or 4D images by additional users without additional computer software, plug-ins, or hardware, to render 3D and 4D medical images for remote collaborative analysis, discussion, and/or diagnoses and that simulate or facilitate imaging of medical procedures for purposes of optimized performance, simulation, training and/or accreditation; as well as generating 3D and/or 4D imaging from 2 or more 2D images and/or projections for such use as semi-automated and/or fully automated, network and/or web-based, 3D and/or 4D imaging.