A chip package structure is provided. The chip package structure includes a first chip, a second chip, and a third chip. The second chip is between the first chip and the third chip. The chip package structure includes a first molding layer surrounding the first chip. The chip package structure includes a second molding layer surrounding the second chip. The chip package structure includes an insulating layer between the first molding layer and the second molding layer and between the first chip and the second chip. A side wall of the first molding layer, a side wall of the second molding layer, and a side wall of the insulating layer are substantially coplanar. The chip package structure includes a third molding layer surrounding the third chip, the first molding layer, the second molding layer, and the insulating layer.