An electronic device that dynamically adapts RTS-CTS protection is described. During operation, this electronic device may obtain communication parameters associated with communication in a WLAN, which includes the electronic device and a second electronic device. For example, the communication parameters may include a collision probability, a PPDU airtime, an RTS airtime, a SIFS airtime and/or a CTS airtime. Then, the electronic device may determine an RTS-CTS performance metric based at least in part on the communication parameters. For example, the RTS-CTS performance metric may be based at least in part on the collision probability, the RTS airtime, the SIFS airtime, and/or the CTS airtime. Next, the electronic device may compare the RTS-CTS performance metric and the PPDU airtime. Moreover, based at least in part on the comparison, the electronic device may selectively use RTS-CTS protection during communication of a PPDU with the second electronic device.