Invention Grant
- Patent Title: Triazole furan compounds as agonists of the APJ receptor
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Application No.: US16347903Application Date: 2017-11-03
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Publication No.: US10736883B2Publication Date: 2020-08-11
- Inventor: Matthew Brown , Ning Chen , Xiaoqi Chen , Yinhong Chen , Alan C. Cheng , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , James S. Harvey , Julie Anne Heath , Lars V. Heumann , Jonathan Houze , Frank Kayser , Aarif Yusuf Khakoo , David j. Kopecky , Su-Jen Lai , Zhihua Ma , Julio C. Medina , Jeffrey T. Mihalic , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Malgorzata Wanska , Wen-Chen Yeh
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Bernard P. Friedrichsen
- International Application: PCT/US2017/059822 WO 20171103
- International Announcement: WO2018/097944 WO 20180531
- Main IPC: A61K31/4196
- IPC: A61K31/4196 ; A61K31/341 ; C07D405/04 ; C07D405/14 ; A61K31/421 ; A61K31/437 ; A61K31/4439 ; A61K31/501 ; A61K31/506 ; C07D239/26 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D471/04 ; C07F7/08 ; A61P9/00 ; A61P9/02 ; C07D307/54
Abstract:
Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.
Public/Granted literature
- US20190275008A1 TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR Public/Granted day:2019-09-12
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